Warning: Wikipedia contains spoilers. Skip the next paragraph if you'd rather be surprised by certain minor gameplay elements.

The game was somewhat notorious for featuring a chainsaw for which there was no fuel, despite many wishful rumours to the contrary. In one of the in-jokes that are a hallmark of the LucasArts adventure games, the second SCUMM game, Zak McKracken and the Alien Mindbenders, contains some fuel, but no chainsaw. In another reference, the entire game is contained within its sequel, Day of the Tentacle, on a computer in the bedroom of one of the characters.

Maniac Mansion was ported to the PC with EGA graphics in 1988. The project leader was Ron Gilbert, and the game was designed by Gilbert and Gary Winnick. Versions for the Apple II, Amiga, and Atari ST computers were also released.

In 1990, Maniac Mansion was ported to the Nintendo Entertainment System, although the game was somewhat censored (i.e. "brains sucked out" changed to "brains removed", graphic of nude sculpture removed, etc.).

The game also spawned a TV series of the same name, featuring several of its characters - notably the Edison family, descendants of that Edison, headed by the mad scientist extraordinaire, Dr. Fred Edison.